Prof. Dr. Oliver Daumke

Oliver Daumke

Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13125 Berlin
Phone: +49 (30) 9406-3425
E-mail: Oliver.Daumke@mdc-berlin.de



Position and Status

Senior group leader at MDC/S-Professor for Structural Biology at Freie Universität Berlin


Scholarships and awards

2014 - ERC Consolidator Grant
2011 - Bayer Early Excellence in Science Award
2011 - EMBO Young Investigator Award
2009 - HFSPO Career Development Award
2007 - HFSPO Long Term Fellowship
2004 - Otto-Hahn Medal of the Max-Planck-Society
2004 - Klaus-Liebrecht Award for best PhD thesis, University Cologne
2001 - Boehringer Ingelheim PhD fellowship



University training and degree

1995 - 2000 - Diplom study of Biology, Universität Freiburg, Sussex (UK) and Köln

 

Advanced academic qualifications

2001 - 2004 - Dr. rer. nat. study with Alfred Wittinghofer, Max Planck Institute of Molecular Physiology, Dortmund

 

Postgraduate professional career

Since 2013 - Permanent Group Leader at the MDC, Berlin, and S-W3 Professor for Structural Biology, Freie Universität Berlin
2010 - 2013 - Junior Professor (W1) at the Institute of Medical Biophysics, Charité, Berlin
2007 - 2013 - Helmholtz University Junior Group Leader at the MDC, Berlin
2004 - 2007 - Postdoctoral Researcher, Laboratory of Molecular Biology, Cambridge, with H. McMahon

Coordinating functions and editorial work

2019 – present Member of the MDC supervisory board

Since 2013 - Vice speaker of the Helmholtz Cross Program Activity 'Structural Biology'
Since 2010 - Board Member, Collaborative Research Center 958

2010 – 2020 - Member Helmholtz Think Tank Board Member

2009 – 2020 - Collaborative Research Center 740 ‘From Molecules to Modules: Organization and Dynamics of Functional Units in Cells’

Most important publications

  1. Melo, A. A., Sprink, T., Noel, J. K., Vázquez-Sarandeses, E., van Hoorn, C., Mohd, S., Loerke, J., Spahn, C. M. T. & Daumke, O. Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments. Nature Communications 13, 7641 (2022). https://doi.org/10.1038/s41467-022-35164-x
  2. Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J. K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M. & Daumke, O. Structural insights into crista junction formation by the Mic60-Mic19 complex. Science Advances 8, eabo4946 (2022). DOI: 10.1126/sciadv.abo4946
  3. Ganichkin, O. M., Vancraenenbroeck, R., Rosenblum, G., Hofmann, H., Mikhailov, A. S., Daumke, O. & Noel, J. K. Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor. Proceedings of the National Academy of Sciences 118, e2101144118 (2021). https://doi.org/10.1073/pnas.2101144118
  4. Grunwald, S., Hopf, L. V. M., Bock-Bierbaum, T., Lally, C. C. M., Spahn, C. M. T. & Daumke, O. Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates. Nature Communications 11, 5506 (2020). https://doi.org/10.1038/s41467-020-19321-8
  5. Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A. A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Blüher, M., Olschowski, H., Kompa, J., Brügger, B., Müller, D. N., Haucke, V., Schürmann, A., Birchmeier, C. & Daumke, O. EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proceedings of the National Academy of Sciences 117, 7471-7481 (2020). https://doi.org/10.1073/pnas.1918415117
  6. Faelber, K., Dietrich, L., Noel, J. K., Wollweber, F., Pfitzner, A.-K., Mühleip, A., Sánchez, R., Kudryashev, M., Chiaruttini, N., Lilie, H., Schlegel, J., Rosenbaum, E., Hessenberger, M., Matthaeus, C., Kunz, S., von der Malsburg, A., Noé, F., Roux, A., van der Laan, M., Kühlbrandt, W. & Daumke, O. Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature 571, 429-433 (2019). https://doi.org/10.1038/s41586-019-1372-3
  7. Turco, E., Witt, M., Abert, C., Bock-Bierbaum, T., Su, M.-Y., Trapannone, R., Sztacho, M., Danieli, A., Shi, X., Zaffagnini, G., Gamper, A., Schuschnig, M., Fracchiolla, D., Bernklau, D., Romanov, J., Hartl, M., Hurley, J. H., Daumke, O. & Martens, S. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Molecular Cell 74, 330-346.e311 (2019). DOI: 10.1016/j.molcel.2019.01.035
  8. Reubold, T. F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D. J., Noé, F., Haucke, V., Daumke, O. & Eschenburg, S. Crystal structure of the dynamin tetramer. Nature 525, 404-408 (2015). https://doi.org/10.1038/nature14880
  9. Faelber, K., Posor, Y., Gao, S., Held, M., Roske, Y., Schulze, D., Haucke, V., Noé, F. & Daumke, O. Crystal structure of nucleotide-free dynamin. Nature 477, 556-560 (2011). https://doi.org/10.1038/nature10369
  10. Gao, S., von der Malsburg, A., Paeschke, S., Behlke, J., Haller, O., Kochs, G. & Daumke, O. Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature 465, 502-506 (2010). https://doi.org/10.1038/nature08972