Prof. Dr. Thomas Höfer
Deutsches Krebsforschungszentrum
und Bioquant Zentrum, Universität Heidelberg
Im Neuenheimer Feld 280
69120 Heidelberg
Phone: +49 (6221) 54-51380
E-mail: t.hoefer@dkfz.de
Head of DKFZ Division, Theoretical Systems Biology Professor of Theoretical Systems Biology (W3)
2019/2020 - Visiting professorship, École Normale Supérieur, Paris
2018 - Offered professorship at Imperial College London and Head of the Integrative Biology section, MRC London Institute of Medical Science (not realized)
2011 - Reinhart Heinrich Lecture, International Study Group for Systems Biology
1994 - 1996 - Jowett Senior Scholar, Balliol College Oxford
1994 - Landahl Award, Society for Mathematical Biology
1993 - 1996 - PhD scholarship, Boehringer Ingelheim Fonds
1991 - 1993 - Studienstiftung des deutschen Volkes
University training and degree
09/1992 - 08/1993 - Diplom (MSc) dissertation, jointly with James D. Murray and Reinhart Heinrich
09/1988 - 07/1992 - Diplom (MSc) studies in Biophysics, Humboldt University Berlin
Advanced academic qualifications
1996 - PhD, with Philip Maini, mathematical sciences, Mathematical Institute, Center of Mathematical Biology, University of Oxford, UK
Postgraduate professional career
2013 - present - Professor (W3), Faculty of Biosciences, Heidelberg University
2011 - present - Head of Division, Theoretical Systems Biology, DKFZ
2007 - 2011 - Group leader (tenured), Modeling of Biological Systems, DKFZ
2002 - 2006 - Junior Professor (W1), Theoretical Biophysics, Humboldt University Berlin
2000 - 2002 - Group leader, Institute of Biology, Humboldt University Berlin
1997 - 2000 - Postdoctoral researcher, Institute of Biology, Humboldt University Berlin
1996 - 1997 - Guest scientist, Max Planck Institute of Complex Biological Systems, Dresden
Coordinating functions and editorial work
2019 - present - Editorial board, Cell Systems
2015 - present - Coordinator, European (ERA CoSysMed) research consortium OPTIMIZE- NB – Optimizing first-line therapies of aggressive neuroblastoma by systems medicine strategies
2013 - present - Editorial board, European Journal of Immunology
2013 - present - Steering committee, Cluster of Excellence CellNetworks (EXC81)
2013 - 2017 - Coordinator, E:Bio Research consortium ImmunoQuant – Multi-scale Modelling of Innate Immune Responses to Viral Infection (funded by Federal Ministry for Education and Research)
2000 - 2006 - Steering committee, DFG Collaborative Research Centre, Theoretical Biology (SFB 618), Humboldt University Berlin
Most important publications
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Körber V, Yang J, Barah Tonn JC, Schackert G, Sabel M, Felsberg J, Zacher A, Kaulich K, Hübschmann D, Herold-Mende C, von Deimling A, Weller M, Radlwimmer B, Schlesner M, Reifenberger G*, Höfer T*, Lichter P* (2019) Evolutionary trajectories of IDH-WT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis. Cancer Cell 35, 692-704
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Li C, Cesbron F, Oehler M, Brunner M*, Höfer T* (2018) Frequency modulation of transcriptional bursting enables sensitive and rapid gene regulation. (*joint corresponding authors) Cell Systems 6, 409-423
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Ryl T, Kuchen EE, Bell E, Shao C, Floréz A, Moenke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T (2017) Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug. Cell Systems 5, 237-250
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Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Klapproth K, Rode I, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T*, Rodewald HR* (2017) Endogenous barcoding reveals hematopoietic stem cell fates realized in vivo. Nature 548, 456-460
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Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz M, Schlenner SM, Reth M, Höfer T*, Rodewald HR* (2015) Fundamental properties of unperturbed hematopoiesis from stem cells in vivo. Nature 518, 542-546
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Buchholz VR#, Flossdorf M#, Hensel I, Kretschmer L, Gräf P, Schiemann M, Höfer T*, Busch DH* (2013) Disparate individual fates compose robust CD8+ T cell immunity. Science 340, 630-635
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Luijsterburg MS, von Bornstaedt G, Gourdin AM, Politi AZ, Moné MJ, Warmerdam DO, Goedhart J, Vermeulen W, van Driel R*, Höfer T* (2010) Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. Journal of Cell Biology 189, 445-463
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Mariani L, Schulz E, Lexberg M, Helmstetter C, Radbruch A, Löhning M, Höfer T (2010) Short-term memory in gene induction reveals the regulatory principle behind stochastic interleukin-4 expression. Molecular Systems Biology 6:359
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Busse D, de la Rosa M, Hobiger K, Thurley K, Flossdorf M, Scheffold A, Höfer T (2010) Competing feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular microenvironments. Proceedings of the National Academy of Sciences of the USA 107, 3058–3063
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Schulz E, Mariani L, Radbruch A, Höfer T (2009) Sequential polarization and imprinting of T-helper type 1 differentiation by interferon-γ and interleukin-12. Immunity 30, 678-688