Dr. Sebastian Schuck

Sebastian Schuck

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH)
Im Neuenheimer Feld 282
69120 Heidelberg
Phone: +49 (6221) 54-6745
E-mail: s.schuck@zmbh.uni-heidelberg.de



Position and Status

Independent junior group leader


Scholarships and awards

2007 - 2010 - Postdoctoral fellowship from the Human Frontier Science Program
2006 - 2007 - Postdoctoral fellowship from the Ernst Schering Foundation
1995 - 2000 - Scholarship Studienstiftung des Deutschen Volkes



University training and degree

03/2000 - 11/2000 - Diploma thesis with Alfred Nordheim at University of Tübingen
09/1997 - 11/2000 - Study of Biochemistry at University of Tübingen
09/1995 - 06/1997 - Study of Biochemistry at University of Hannover

 

Advanced academic qualifications

2004 - PhD (Dr. rer. nat.) in Biology, Technical University Dresden, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Supervisor: Kai Simons

 

Postgraduate professional career

07/2013 - present - Independent group leader at Heidelberg University, Center for Molecular Biology
09/2006 - 06/2013 - Postdoctoral fellow with Peter Walter at the University of California, San Francisco, USA
01/2005 - 08/2006 - Postdoctoral fellow with Kai Simons at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden

Most important publications

  1. Schäfer JA, Schessner JP, Bircham PW, Tsuji T, Funaya C, Pajonk O, Schaeff K, Ruffini G, Papagiannidis D, Knop M, Fujimoto T, Schuck S. ESCRT machinery mediates selective microautophagy of endoplasmic reticulum. EMBO J, e102586 doi: 10.15252/embj.2019102586.

  2. Schmidt RM, Schessner JP, Borner GH, Schuck S (2019) The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance. eLife 8:e43244

  3. Szoradi T, Schaeff K, Garcia-Rivera EM, Itzhak DN, Schmidt RM, Bircham PW, Leiss K, Diaz-Miyar J, Chen VK, Muzzey D, Borner GH, Schuck S (2018) SHRED Is a Regulatory Cascade that Reprograms Ubr1 Substrate Specificity for Enhanced Protein Quality Control during Stress. Mol. Cell 70:1025-1037

  4. Schuck S, Gallagher CM, Walter P (2014) ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J. Cell Sci. 127:4078-4088

  5. Moreira* KE, Schuck* S, Schrul B, Frohlich F, Moseley JB, Walther TC, Walter P (2012) Seg1 controls eisosome assembly and shape. J. Cell Biol. 198:405-420

  6. Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P (2011) Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J. Cell Biol. 193:171–184

  7. Schuck S, Prinz WA, Thorn KS, Voss C, Walter P (2009) Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J. Cell Biol. 187:525-536

  8. Schuck* S, Gerl* MJ, Ang A, Manninen A, Keller P, Mellman I, Simons K (2007) Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic 8:47–60

  9. Schuck* S, Manninen* A, Honsho M, Füllekrug J, Simons K (2004) Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc. Natl. Acad. Sci. U.S.A. 101:4912–4917

  10. Schuck* S, Honsho* M, Ekroos K, Shevchenko A, Simons K (2003) Resistance of cell membranes to different detergents. Proc. Natl. Acad. Sci. U.S.A. 100: 5795–5800