Prof. Dr. Britta Brügger

Britta Brügger

Biochemie-Zentrum der Universität Heidelberg (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
Phone: +49 (6221) 54-5326
E-mail: Britta.Bruegger@bzh.uni-heidelberg.de


Research Area

Molecular Cell Biology, Biochemistry, Chemical Biology


Position and Status

Professor of Biochemistry / Chemical Biology (W3)


Scholarships and awards

2015 - Walter A. Shaw Young Investigator Award in Lipid Research
2000 - 2002 - Postdoctoral fellowship (Peter and Traudl Engelhorn Program)
1998 - 2000 - Postdoctoral fellowship (EMBO long-term fellowship)
1998 - Ph.D. degree with summa cum laude



University training and degree

09/1993 - 06/1994 - Diploma thesis with Hans-Dieter Söling at Georg-August-Universität Göttingen
10/1988 - 08/1993 - Study of Biology (Vordiplom) and Biochemistry (Diplom) at Johann Wolfgang von Goethe University Frankfurt

 

Advanced academic qualifications

12/2006 - Habilitation (venia legendi) in Biochemistry, Ruprecht-Karls-Universität Heidelberg; Mentor: Felix T. Wieland
10/1998 - PhD. in Biochemistry (Dr. phil. nat.), Johann Wolfgang von Goethe University Frankfurt, Mentor: Felix Wieland, Heidelberg University

 

Postgraduate professional career

10/2014 - present - Professor of Biochemistry/Chemical Biology at Heidelberg University Biochemistry Center, Faculty of Biosciences
05/2002 - 09/2014 - Research Fellow at the Heidelberg University Biochemistry Center
05/2000 - 04/2002 - Post-doctoral research fellow with Felix T. Wieland at the Heidelberg University Biochemistry Center
06/1998 - 04/2000 - Post-doctoral research fellow with James E. Rothman at Memorial Sloan-Kettering Cancer Center, New York, USA

Coordinating functions and editorial work

2016 - present - Member of the DFG review board Life Sciences - Biochemistry
2014 - 09/2019 - Dean of Studies, Biochemistry
2009 - present - Section Editor, BBA Molecular and Cell Biology of Lipids
2010 - present - Vice-Chair of CRC/Transregio 83 "Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies"

Most important publications

  1. Hammerschmidt P, Ostkotte D, Nolte H, Gerl, MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC (2019) CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell 177 (6): 1536-1552

  2. Hacke M, Björkholm P, Hellwig A, Himmels P, de Almodóvar CR, Brügger B, Wieland F, Ernst AM (2015) Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol. Nat Commun. 9;6:7688

  3. Björkholm P, Ernst AM, Hacke M, Wieland F, Brügger B*, von Heijne G* (2014) Identification of novel sphingolipid-binding motifs in mammalian membrane proteins. Biochim Biophys Acta 1838(8):2066-70

  4. Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, and Brügger B (2012) Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature 481(7382): 525-9

  5. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319(5867):1244-7

  6. Haberkant P, Schmitt O, Contreras FX, Thiele C, Hanada K, Sprong H, Reinhard C, Wieland FT, Brügger B (2008) Protein-sphingolipid interactions within cellular membranes. J Lipid Res. 49(1):251-62

  7. Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG (2006) The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A. 103(8):2641-6

  8. Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R (2006) Molecular anatomy of a trafficking organelle. Cell 127(4):831-46

  9. Brügger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT (2000) Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 151(3):507-18

10. Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD (1997) Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94(6):2339-44