Prof. Dr. Elke Krüger

Prof. Dr. Elke Krüger

Universitätsmedizin Greifswald
Institut für Medizinische Biochemie und Molekularbiologie
F.-Sauerbruchstr. Klinikum/ DZ7
17475 Greifswald
Phone: +49 (3834) 86 5400
Fax: +49 (3834) 86 5402
E-mail: elke.krueger@uni-greifswald.de


Research Area

Molecular Cell Biology, Biochemistry, Immunology


Position and Status

Professor of Medical Biochemistry and Molecular Biology (W3) and Chair of the Institute of Medical Biochemistry and Molecular Biology


Scholarships and awards

2007               Charité award “Personal Research promotion” (career support)
1996               1996 PhD thesis award of the EMAU
1993 - 1996    PhD student stipend and member of the DFG Graduate School „Structural and functional characterization of pro- and eukaryotic genes“ EMAU
1991 - 1992    Student fellowship of the EMAU Greifswald undergraduate program



Academic Education

11/1992 - 06/1996   Ph.D. thesis with Michael Hecker at the Ernst-Moritz-Arndt-University Greifswald (EMAU)
11/1991 - 10/1992   Diploma thesis with Michael Hecker at the EMAU Greifswald
10/1987 - 10/1991   Study of Biology, EMAU Greifswald

 

University Degrees

2008   Habilitation (venia legendi) in Biochemistry, Charité Universitätsmedizin Berlin, Mentor: Peter-M. Kloetzel
1996   Ph.D. in Microbiology; EMAU Greifswald, Mentor: Michael Hecker (summa cum laude)
1992   Diploma in Molecular Microbiology, Genetics, Biotechnology, and Biochemistry, EMAU Greifswald

 

Employment

03/2017 -                 Professor of Medical Biochemistry and Molecular Biology (W3), Chair of the Institute of Medical Biochemistry and Molecular Biology
02/2014 - 02/2017   Professor of Biochemistry at the Charité Universitätsmedizin Berlin (W2 unlimited)
02/2009 - 01/2014   Professor of Biochemistry at the Charité Universitätsmedizin Berlin (W2 Tenure Track)
01/2000 - 01/2009   Group leader at the Institute of Biochemistry, Charité Universitätsmedizin Berlin; “Proteasome assembly”
03/1999 - 12/1999   Postdoctoral researcher with Peter-M. Kloetzel at the Institute of Biochemistry, Charité Universitätsmedizin Berlin
07/1996 - 02/1999   Postdoctoral researcher with Michael Hecker at the Institute for Microbiology EMAU Greifswald, “Bacterial stress responses”; “Bioprocess scale up strategy based on integration of microbial physiology and fluid dynamics”

Coordinating Functions and Editorial Work

2015 - present   Deputy Chair Institute of Biochemistry, Charité
2014 - present   Director of studies Biochemistry of the Medical Faculty Charité
2009 - present   Elected member of gender equality committee of the Medical Faculty Charité
2007 - present   Elected member of the steering committee of the SFB740, Project area B “Control of conformation and degradation of proteins”

  1. Brehm A, LiuY, Sheikh A, Omoyinmi E, Biancotto A, Montealegre G, Reinhardt A, Almeida de Jesus A, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Zhou Q, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Ling G, Plass N, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CCR, Kastner DL,Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Rother K, Hildebrand PW, Brogan P Krüger E,*1 Aksentijevich I1 , Goldbach-Mansky R.* 1 (2015) Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production,*corresponding author 1 equal contribution J Clin Invest. 125:4196-4211.
  2. Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter A, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E. (2013) Immunoproteasomes Are Important for Proteostasis in Immune Responses. Cell 152:935-937. Correspondence
  3. Krüger E, Kloetzel PM. (2012) Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme. Curr Opin Immunol. 24:77-83.
  4. Kriegenburg, F, Poulsen EG, Koch A, Krüger E*, and Hartmann-Petersen R. *(2011) Redox control of proteasomal function: From molecular mechanisms to functional significance. Antioxid Redox Signal. 15(8):2265-2299. *corresponding authors
  5. Steffen J, Seeger M, Koch A, and Krüger E. (2010) Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD dependent feedback loop. Mol Cell 40(1):147-158.
  6. Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, and Krüger E. (2010) Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 142: 613-624.
  7. Fricke B, Heink S, Kloetzel PM, and Krüger E. (2007) POMP facilitates 20S Proteasome Formation at the Endoplasmic Reticulum. EMBO Rep. 8:1170-1175.
  8. Heink S., Ludwig D., Kloetzel PM., and Krüger E. (2005) Interferon- induced immune-adaptation of the proteasome system is an accelerated and transient response. Proc Natl Acad Sci U.S.A. 102: 9241-9246.
  9. Meiners S, Heyken D, Weller A, Ludwig A, Stangl K, Kloetzel PM, Krüger E. (2003) Inhibition of Proteasome Activity Induces Concerted Expression of Proteasome Genes and de novo Formation of Mammalian Proteasomes. J Biol Chem. 278: 21517-21525.
  10. Krüger E., Zühlke D., Witt E., Ludwig H., and Hecker M. (2001) Clp-mediated proteolysis in Grampositive bacteria is autoregulated by the stability of a repressor. EMBO J. 20:852-863.