Dr. Doris Höglinger

Dr. Doris Höglinger

Biochemie-Zentrum der Universität Heidelberg (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg
Phone: 06221 54-4181
E-mail: Doris.Hoeglinger@bzh.uni-heidelberg.de



Position and Status

Junior group leader 


Scholarships and awards

2016 - 2017- European Blaschko Visiting Research fellowship
2016 - 2017 - Linacre College Junior Research fellowship
2016 - 2017 - Rosetrees Trust postdoctoral fellowship
2012 - 2015 - Marie-Curie Actions ITN fellowship “Sphingonet"



University training and degree

10/2010 - 06/2011 - Diploma work at the Johannes Kepler University Linz, Institute for Biophysics, supervised by Dr. Hermann Gruber
10/2005 - 06/2011 - Study of Technical chemistry at the Johannes Kepler University Linz

 

Advanced academic qualifications

2015 - Ph.D. degree in Biology, co-awarded by the European Molecular Biology Laboratory and University of Heidelberg, supervised by Dr. Carsten Schultz

 

Postgraduate professional career

04/2017 - present - Junior group leader at Heidelberg University, Biochemistry center
02/2016 - 03/2017 - Postdoctoral fellow with Prof. Platt, Department of Pharmacology, University of Oxford

Most important publications

  1. Höglinger D, Burgoyne T, Sanchez-Heras E, Hartwig P, Colaco A, Newton J, Futter C, Spiegel S, Platt F, Eden E. (2019). NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress. Nat Commun, 10(1):4276, doi: 10.1038/s41467-019-12152-2.

  2. Höglinger D. (2019) Bi- and Trifunctional Lipids for Visualization of Sphingolipid Dynamics within the Cell. Methods Mol Biol, 1949:95-103, doi: 10.1007/978-1-4939-9136-5_8.

  3. Wagner N, Stephan M, Höglinger D, Nadler A. (2018) A click cage: Organelle-specific uncaging of lipid messengers. Angew Chem Int Ed Engl, 57, 1-6, doi: 10.1002/anie.201807497

  4. Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C. (2017) Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
    Proc Natl Acad Sci U S A, 114(7):1566-1571, doi: 10.1073/pnas.1611096114

  5. Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Willians A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM. (2016) Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway. Wellcome Open Res 1:18, doi: 10.12688/wellcomeopenres.10036.1

  6. Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C. (2016) Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. ACS Chem Biol 11(1):222-30, doi: 10.1021/acschembio.5b00810

  7. Höglinger D, Haberkant P, Aguilera-Romero A, Riezman H, Porter FD, Platt FM, Galione A, Schultz C. (2015) Intracellular sphingosine releases calcium from lysosomes. ELife doi:10.7554/eLife.10616

  8. Höglinger D, Nadler A, Schultz C. (2014) Caged lipids as tools for investigating cellular signaling. Biochim Biophys Acta 1841(8):1085-96